Cheung Yat Kin (Kenneth Ma) recently graduated and started his practice in neurosurgery at Yan Oi Hospital. Kin is a goal-driven individual who took his work seriously and strictly followed the rules. Although his medical interns were afraid of his strict rules and high expectations, they respected his exceptional skills and experiences. Kin initially studied medicine because he was grateful to the doctor (Yu's father) who saved his younger brother Cheung Yat Hong’s (Nathan Ngai) life after a bad traffic accident. Kin took great care of his brother and worked hard to earn enough money to send his brother for an overseas's education. Because he was worried that his brother will be unable to take care of himself as his legs are paralyzed, Kin decided that his mother shall accompany his brother overseas. Thus Kin had to work doubly hard to enough money to support both of them. Kin’s incredible work ethic enabled him to work hard and save enough money to support his brother financially. For that reason, Kin did not consider being committed into a relationship until he met Fan Chi Yu (Tavia Yeung). Yu, a reputable doctor, worked on several projects with Kin and found herself falling in love with him. However, when she found out that her long lost sister, Fan Mei Suet (Mandy Wong), also liked Kin, she decided to give up on pursuing him. Subsequently, Kin realized that he also had feelings for Yu when she stopped talking to him and confessed his love to her. Shortly after Kin and Yu started their relationship, Hong got into accident and tragically died. Kin’s grief over his younger brother’s tragic death greatly influenced his attitude towards his interns, especially Yeung Pui Chung (Him Law), who Kin had always considered him as a younger brother. To make matters worse, Kin suddenly finds out that Yu suffers from tumor in her spine and that it may become life-threatening. Yu actively searched for treatment and her persistent spirit motivated Kin to get back on his feet to support her. Unfortunately, Yu’s condition worsened, and she took the risk of undergoing a dangerous surgery. As a doctor and Yu’s boyfriend, Kin and Yu's father took on the challenge to do the surgery on her. After enduring the hardships together, Kin and Yu’s feelings grew deeper and got happily married.

The Blind Swordsman returns for the final time in his ground-breaking television series. As exciting and well made as many of his films, Zatoichi’s travels around the nation are chronicled as he finds himself embroiled in the lives of those who desperately need his help. Katsu Shintaro is brilliant in his signature character while maintaining the highest standards of film making.

Wataru (Takashi Sorimachi) goes back to the Tokyo Metropolitan Police Department after finishing training at the police academy, but he is assigned to the public relations division and not to investigation department. Meanwhile, Hatsue Kurusu goes to the #1 investigation division and claims to have killed Futoshi Miyata. Three days ago, Futoshi’s dead body was found at an irrigation channel and the police concluded that he died by accidental drowning. Hatsue Kurusu asks to be punished for his actions. Ukyo (Yutaka Mizutani) takes an interest in Hatsue’s appeal and begins an investigation by himself.

Rerin, the textile professor goes to take vacation in Chiang Mai because she wants to have time to think over about her relationship with Thanin, her fiance. On her vacation, she meets Suriyawong, the owner of The Chang Restaurant in Chiang Mai who descends from the prince and Grandma Bua Ngern. Suriyawong falls in love at first sight with Rerin and feels like she's someone who he has longed for. However, Wongprajan, Suriyawong's relative and the owner of Le Laos Restaurant comes in to obstruct their love and declare herself as his fiancee.

Shek Chi Hong is now the number one "God of Gamblers" in the gambling world. He is a genius in gambling but prefers a quiet life. However, he can’t change his own destiny as long as he hasn’t retired from the gambling world.

Knowing that Hung Fung's gambling skills have improved tremendously over the years, Cheung Tin Jing resorts to inviting Chi Hong to help him. Chi Hong refuses to step into the gambling world again due to the promise to his wife. It is not until Cheung Tin Jing fakes a heart attack that Ah Kong decides to help him finally. There, he meets Cheung Tin Jing's only daughter, Cheung Sik Yu and her childhood friend, Dik San.

However, after his helping in Tin Ding winning over Mun Long, this in turn causes his wife's death. Since then, he becomes disillusioned in life.

The basketball genius Zhong Dahai suddenly turned into a girl after an accident. Even so, he has not forgotten his dream and joins the basketball team as a cheerleader by accident. In order to conceal his identity, he has to act in front of his "good brother" Lu Xing Qi while coping with Ye Ran's surveillance sent by the attending doctor. The situation was full of jokes! However, in fact, Zhong Dahai himself is a girl with gender disorder, and has always mistaken himself for a boy because of his illness.

Sequel to Mr. Bodyguard 3.